Double-click EN20Inst in the window containing your extracted files.click Extract at the bottom of the new window.click Extract all files at the top of the window.* PC users please note: After downloading the zipped installation file After installing EndNote, open the application and check for updates (Windows: under Help Mac: under EndNote 20) to ensure you are working with the most up-to-date version of EndNote.
You will be downloading a zipped (compressed) file containing an EndNote software package licensed only for University of Lethbridge users. When you download EndNote for your use, you will be asked to agree to the terms of the University of Lethbridge site license and to validate your relationship with the University by entering your username and password. Also before installing, make sure you close all Word processing applications and all Microsoft Office applications. Doing so will also prevent you from using earlier versions of EndNote to edit (and possibly corrupt) any EndNote libraries you may already have created. We recommend that you remove previous versions of EndNote before updating to the current version to allow for a clean, trouble-free installation of the software. 
Some things to consider before you begin:
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